It should be particularly useful for researchers who are beginning investigations in this area of cell biology. This review is intended to summarize the knowledge accumulated, to date, by workers in this field. However, there are many different protocols for the induction and differentiation of NSCs, and these result in a wide range of neural cell types. The most convenient and acceptable source of NSCs is pluripotent stem cells (embryonic stem cells or induced pluripotent stem cells). Such cells also have an application in regenerative medicine. Neural stem cells (NSCs) provide promising approaches for investigating embryonic neurogenesis, modeling of the pathogenesis of diseases of the central nervous system, and for designing drug-screening systems. 3Koltzov Institute of Developmental Biology of the Russian Academy of Sciences, Moscow, Russia.
2Center for Precision Genome Editing and Genetic Technologies for Biomedicine, Pirogov Russian National Research Medical University, Moscow, Russia.1Faculty of Biology, Lomonosov Moscow State University, Moscow, Russia.
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